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These patients are much more likely to have classical EGFR mutations in the small cell component of their tumors as well, and their tumors seem to be more likely to respond to treatment with EGFR-TKI's.
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Multiple trials have evaluated chemotherapy treatment options for stage IV NSCLC.
During the past few years, the seminal discovery of activating mutations in the kinase domain of the epidermal growth factor receptor ( EGFR) gene has revolutionized the treatment of non-small cell lung cancer (NSCLC).
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The percentage of patients that must respond to a drug before it is approved by the FDA varies from as high as 80% to as low as 20%.
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