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Hepatic damage from NSAIDs is rare, but these medications should not be used in persons with cirrhotic liver diseases because bleeding problems and renal failure are more likely.

Evidence may include but is not limited to: research findings, literature, bench-marking data, clinical experts, quality improvement, risk management data, and standards and guidelines.

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COX-2 Inhibitors - (Cyclooxygenase-2) celecoxib is very useful for orthopedic surgery, dental surgery, dysmenorrhea and have fewer side effects than NSAIDs with equal efficacy.

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Unlike other NSAIDs (such as and ) that target both the COX-1 and the COX-2 enzymes, celecoxib only targets the COX-2 enzyme.

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Study Selection: Systematic reviews and randomized trials of dual therapy or monotherapy with 1 or more of the preceding medications for acute or chronic low back pain that reported pain outcomes, back-specific function, general health status, work disability, or patient satisfaction.

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